Hi @Jimk_Aero ,
Sorry to hear about the problems. Not being able to power off USB does make this hard and is a carry over from the VOXL Flight....
Even without ESC calibration, you can manually attempt to spin a motor, if using PWM, via this: https://dev.px4.io/master/en/middleware/modules_command.html#pwm
Do you have an oscilliscope? You could probe the PWM channel output pretty easy (pins 2-5 for a quad) and see if you see any signal coming out of the board. If there's no signal, when you expect it, on a single channel, try to look at those ESD diodes right next to the connector and check for any fried parts.
PX4 FW version you are running? There are two programs to handle some edge cases, px4-esc-cal-tool-v1-11.py and px4-esc-cal-tool.py