Hi Asif,
I'm not totally sure about the final use case (sensor driver and sensor implementations vary) but I can comment on the I2Cs on the hardware. In general you can have multiple I2C devices on the same bus (given they have ability to change slave addresses), so you may get away with multiples on a bus?
I2C1 at J10 --> here normal use case is a magnetometer but yes you could use this, provided the driver looks for this port
I2C2 at J14 -> here - this is 'spare' in our generic use case so should be OK
Can you share PN of what you're trying to use? We don't have direct experience with ToF from Flight Core at this point to reference